Isabella, Princess of Asturias (1470 – 1498). Queen consort of Portugal and heir presumptive of King Ferdinand II of Aragon and Queen Isabella I of Castile, as their eldest daughter. Her younger sisters were Catherine, Queen of England, Queen Joanna I of Castile, and Maria, Queen of Portugal.
She was Queen of Portugal as the wife of King Manuel I from 30 September 1497 until her death the next year. Manuel later married Isabella's younger sister, Maria.
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